Table 1.

Clinicopathological characteristics

Variable		n = 206		High TP (n = 42)		Medium TP (n = 133)		Low TP (n = 31)		p value
Mean age (years)		70.0 ± 11.3		73.9 ± 12.2		68.6 ± 11.4		70.8 ± 8.3		0.013
Mean follow-up (years)		5.3 ± 3.5		4.8 ± 3.5		5.7 ± 3.6		4.4 ± 2.7		0.139
Mean lymph node harvest (n)		23 ± 13		19 ± 8		24 ± 14		26 ± 15		0.084
Positive lymph nodes (n)		1.2 ± 2.3		0.9 ± 1.9		1.1 ± 2.3		1.7 ± 2.4		0.485
Sex										0.934
	Female	88	43%	17	40%	58	44%	13	42%
	Male	118	57%	25	60%	75	56%	18	58%
T status										0.988
	pT3	180	87%	37	88%	116	87%	27	87%
	pT4	26	13%	5	12%	17	13%	4	13%
Nodal status										0.742
	Negative	128	62%	28	67%	82	62%	18	58%
	Positive	78	38%	14	33%	51	38%	13	42%
Vascular invasion										0.587
	Negative	186	90%	39	93%	118	89%	29	94%
	Positive	20	10%	3	7%	15	11%	2	6%
Lymphovascular invasion										0.061
	Negative	171	83%	40	95%	106	80%	25	81%
	Positive	35	17%	2	5%	27	20%	6	19%
Grading										0.394
	Low grade	141	68%	29	69%	94	71%	18	58%
	High grade	65	32%	13	31%	39	29%	13	42%
Tumor budding										0.029
	Bd 1	168	82%	38	90%	109	82%	21	68%
	Bd 2	25	12%	3	7%	18	14%	4	13%
	Bd 3	13	6%	1	2%	6	5%	6	19%
Location										0.999
	Right	127	62%	26	62%	82	62%	19	61%
	Left	79	38%	16	38%	51	38%	12	39%
Microsatellite status										0.132
	MSS	180	87%	38	90%	112	84%	30	97%
	MSI	26	13%	4	10%	21	16%	1	3%
Distant metastasis										0.003
	No	165	80%	28	67%	116	87%	21	68%
	Yes	41	20%	14	33%	17	13%	10	32%
Death										0.003
	No	121	59%	16	38%	89	67%	16	52%
	Death	85	41%	26	62%	44	33%	15	48%
5-year survival (n = 160)										0.042
	Survived	97	61%	18	49%	67	68%	12	48%
	Death	63	39%	19	51%	31	32%	13	52%

p values are shown for difference between the low, medium, and high tumor proportion group, classified by cutoffs at FroTP

MSI microsatellite instable, MSS microsatellite stable