Table 3.

p values and hazard ratios for univariate and multivariate analyses

	Univariate analyses			Multivariate Cox regression analyses
Variable	Distant metastasis n = 206	Overall survival n = 206	5-year survival n = 160	Distant metastasis, hazard ratio, and 95% CI	P value	Overall survival hazard ratio, and 95% CI	p value
Sex	0.18	0.66	0.639
Mean age (years)	0.096	< 0.001	0.002		0.17
> = 70 years						2.2 (1.4–3.6)	0.001
< 70 years
Mean lymph node harvest	0.14	0.24	0.573
> = 23 lymph nodes
< 23 lymph nodes
T status	< 0.001	0.018	0.012
T3
T4				4.7 (2.3–9.7)	< 0.001	2.2 (1.2–3.9)	0.01
Nodal status (+ vs. -)	0.06	0.25	0.468		0.69
Vascular invasion	0.19	0.49	0.64
Lymphovascular invasion	0.04	0.39	0.133		0.14
Grading	0.34	0.89	0.697
Tumor budding	0.02	0.34	0.179	1.6 (1.003–2.4)	0.048		0.23
Sidedness	0.047	0.669	0.598		0.071
Microsatellite status	0.03	0.23	0.374
MSS							0.14
MSI				0.12 (0.02–0.92)	0.04
Tumor proportion (FroTP)	0.001	0.002	0.042
High tumor proportion				3.2 (1.6–6.7)	0.001	2.1 (1.3–3.4)	0.004
Medium tumor proportion
Low tumor proportion				2.7 (1.2–6.0)	0.016	2.0 (1.1–3.7)	0.02
Tumor proportion (MinTP)	0.009	0.01	0.084		ns		ns
Distant metastasis		< 0.001	< 0.001

CI confidence interval, MSI microsatellite instable, MSS microsatellite stable, ns not significant

FroTP region at invasion front with deepest infiltration; MinTP region with suspected lowest tumor proportion