Figure 6.

Ex vivo cytokine expression profile of CD8 T cells during HTLV-1 infection. Cryopreserved PBMCs from 17 AC, 5 HAM/TSP patients and 3 SC were immunophenotyped for various intracellular cytokine expression in CD8 T cells after stimulation with PBS (unstimulated) or with HTLV-1 derived from MT-2 cell culture supernatants for 16 h. Frequency of CD3+CD8+ T cells expressing IFN-γ (A), CD107a (B), TNF-α (C), and IL-2 (D) are shown. Significant differences between groups were calculated using Dunn's multiple comparisons test with p-values < 0.05 considered to be significant.