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. 2021 Feb 15;81(2):283–289. doi: 10.1007/s40265-020-01464-z
An orally active farnesyltransferase inhibitor being developed by Eiger BioPharmaceuticals under license from Merck & Co. for the treatment of progeria and progeroid laminopathies.
Received its first approval on 20 November 2020 in the USA.
Approved to reduce the risk of mortality in HGPS and for the treatment of processing-deficient progeroid laminopathies in patients ≥ 12 months of age with a BSA of ≥ 0.39 m2.