Fig. 1.

Representative image of PDAC and its microenvironment. A high stromal content (vimentin, blue) surrounds malignant pancreatic ducts (red). Lymphocytic infiltration (CD3, green) is sparse and, generally, away from the tumor cells. Myeloid cells (CD68, purple) can be abundant and often possess immune suppressive features. All these factors, together with a poor vascularization, constitute major obstacles to the success of immunotherapeutic approaches in pancreatic cancer. The image was obtained through imaging mass cytometry analysis as reported before [183]