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. 2021 Mar 9;11:638171. doi: 10.3389/fonc.2021.638171

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Copyright © 2021 Qiu, Xiong, Fu, Dong, Liu, Peng, Jin, Zhou, Xu, Huang, Fu, Xu, Tu and Yu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Co-expression of GPER and p-ERK predicts improved prognosis for HCC patients. (A) Representative GPER and p-ERK staining in 141 HCC specimens. GPER was detected in the cytoplasm, while p-ERK was mostly expressed in the nucleus (400× magnification, scale bar = 50 μm). (B) Significantly different IHC staining of p-ERK in GPER-positive tissue compared with that in GPER-negative tissue (P < 0.0001). (C) Western blot of GPER and p-ERK proteins in six frozen HCC tissue samples (T1–T6). (D) Kaplan–Meier plots for OS vs. GPER/p-ERK status. Patients with HCC and high GPER/ERK activation are predicted to have better outcomes than those with other subtypes. The median OS times of GPER^-/p-ERK^-, GPER⁺/p-ERK^-, GPER^-/p-ERK⁺ and GPER⁺/p-ERK⁺ patients were 9.5, 10.4, 19.3 and 22.9 months, respectively (P < 0.0001).