Table 4.
Clinical trials target on GSCs or adopt NSCs as therapeutic means
| NCT number | Title | Status | Target or medium | Therapy |
|---|---|---|---|---|
| NCT02039778 | Stem cell radiotherapy and temozolomide for newly diagnosed high-grade glioma | Terminated | GSCs | Radio- and chemo-therapy |
| NCT03072134 | Neural stem cell-based virotherapy of newly diagnosed malignant glioma | Completed | NSCs | Virotherapy |
| NCT01872221 | Study of the capacity of the MRI spectroscopy to define the tumor area enriched in glioblastoma stem cells. Proof of concept study | Completed | GSCs | Radio- and chemo-therapy |
| NCT02192359 | Carboxylesterase-expressing allogeneic neural stem cells and irinotecan hydrochloride in treating patients with recurrent high-grade gliomas | Recruiting | NSCs | Genetically modified therapy |
| NCT01172964 | A pilot feasibility study of oral 5-fluorocytosine and genetically modified neural stem cells expressing E. Coli cytosine deaminase for treatment of recurrent high-grade gliomas | Completed | NSCs | Genetically modified therapy |
| NCT02010606 | Phase I study of a dendritic cell vaccine for patients with either newly diagnosed or recurrent glioblastoma | Active, not recruiting | GSCs | Immunotherapy |
| NCT02055196 | Genetically modified stem cells and irinotecan hydrochloride in treating patients with recurrent high-grade gliomas | Withdrawn | NSCs | Genetically modified therapy |
| NCT02015819 | Genetically modified neural stem cells, flucytosine, and leucovorin for treating patients with recurrent high-grade gliomas | Active, not recruiting | NSCs | Genetically modified therapy |
| NCT01171469 | Vaccination with dendritic cells loaded with brain tumor stem cells for progressive malignant brain tumor | Completed | GSCs | Immunotherapy |
| NCT03956706 | Study of stereotactic radiosurgery to the subventricular zone in malignant gliomas | Recruiting | NSCs | Radiotherapy |
| NCT01567202 | Study of DC vaccination against glioblastoma | Recruiting | GSCs | Immunotherapy |
| NCT00473408 | The effect of radiotherapy and temozolomide on the tumor vasculature and stem cells in human high-grade astrocytomas | Terminated | GSCs | Radio- and chemo-therapy |
| NCT03632135 | Standard chemotherapy vs. chemotherapy guided by cancer stem cell test in recurrent glioblastoma | Recruiting | GSCs | Chemotherapy |
| NCT02654964 | Cancer stem cell high-throughput drug screening study | Unknown status | GSCs | Chemotherapy |
| NCT03548571 | Dendritic cell immunotherapy against cancer stem cells in glioblastoma patients receiving standard therapy | Recruiting | GSCs | Immunotherapy |
| NCT00846456 | Safe study of dendritic cell (DC) based therapy targeting tumor stem cells in glioblastoma | Completed | GSCs | Immunotherapy |
| NCT00890032 | Vaccine therapy in treating patients undergoing surgery for recurrent glioblastoma multiforme | Completed | GSCs | Immunotherapy |
| NCT01400672 | Imiquimod/brain tumor initiating cell (BTIC) vaccine in brain stem glioma | Terminated | GSCs | Radio- and immune-therapy |
| NCT02177578 | Subventricular zone (SVZ) and temozolomide in glioblastoma multiforme | Recruiting | NSCs | Radio- and chemo-therapy |