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. 2021 Mar 22;11:6489. doi: 10.1038/s41598-021-85833-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Biodistribution of GF-EVs loaded with ¹²⁵I-labeled BSA and free ¹²⁵I-BSA in mice 2 h after intravenous administration. Analysis of the radioactive protein abundance in different tissues expressed as a percentage of injected dose (ID) per gram of tissue (A) or as a percentage of relative blood dose (RBD) per gram of tissue (B). N = 3. Data are presented as means ± SD. *, p < 0.05; **, p < 0.01 as estimated by unpaired Student’s t-test analysis.