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. 2021 Mar 22;11:6581. doi: 10.1038/s41598-021-85820-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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MRI-guided transplantation of stem cells. (A) MRI-guided intraarterial transplantation of SPION labeled canine GRPs in DM dogs. (B) MRI-guided intraarterial transplantation of SPION labeled porcine MSCs in pig. (C) MRI-guided intraarterial transplantation of SPION canine MSCs in DM dogs. (D) Brain area covered by transplanted GRP cells during and post injection in DM dogs. (E) Brain area covered by transplanted MSC cells during and post injection in DM dogs. Data are expressed as mean with standard deviation (SD) and differences were considered as statistically significant at the 95% confidence level (***P < 0.001).