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. 2021 Mar 22;11:6556. doi: 10.1038/s41598-021-86120-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Differential gene expressions of the chemoresistant MX-1 cell sublines. (A–D) Results from quantitative PCR (qPCR) analysis showing the comparative mRNA expression of Epithelial–mesenchymal transition related genes in the parental MX-1 and chemoresistant cells, cultured with increasing concentrations (10 nM, 20 nM, 40 nM and 80 nM) of doxorubicin (MX-1/D), ABCB1 transporter activator TPP⁺ (MX-1/T) or both (MX-1/TD). (E) Western blot analysis of the protein expression of CDH1 and CDH2 in MX-1 and MX-1/D80 cells. (F–H) Relative expression level of cancer stem cells related genes. The graphs show the mean (± SEM) ratio of the indicated gene expression compared to endogenous control HPRT1 expression. Indicated P values were calculated based on paired t-tests.