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. 2021 Mar 9;12:632466. doi: 10.3389/fgene.2021.632466

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Copyright © 2021 Ye, Liu, Wang, Dai, Qiao, Gao and Liao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pedigrees, YWHAG mutations and EEG changes in the proband. (A) Pedigrees of the families with YWHAG mutations. Individuals with mutation are indicated by m/+, and those negative for mutation are indicated by +/+. (B) Sequencing chromatograms of c.124C>T and c.373A>G. (C) The amino acid sequence alignment of 14-3-3γ showed that the residue Lys125 was highly conserved in various species. (D) Ictal EEG changes in the proband with mutation Arg42Ter showed myoclonic seizures with generalized irregular polyspike-and-slow waves (obtained at the age of 1 year). (E) Interictal EEG changes in the proband with mutation Lys125Glu showed generalized spike-and-slow waves (obtained at the age of 2 years).