Figure 3.

14-3-3γ dimer forming and its association with phenotypical variation. (A) A front view of 14-3-3γ monomer shows the location of the missense mutations. (B) A lateral view of 14-3-3γ dimer. The peptide-binding grooves are colored as green surface. (C) Difference in the pathogenic mechanism between heterozygous truncating mutation and heterozygous missense mutation. A heterozygous truncating mutation would lead to only decreasing the number of wild-type dimer, whereas a heterozygous missense mutation would lead to majority dimers being mutants. The binding groove with missense mutation is colored red.