Figure 2.

ACRCelerate: Colorectal Cancer Stratified Medicine Network Platform design and governance. Project proposals arising from industry partners, academics or clinicians will be submitted to a preclinical therapeutic committee for discussion. Execution of the project will be allocated to the various hubs based on centre expertise and interest before cross centre validation is undertaken. We also seek to develop complementary circulating tumour cell-derived organoid (CDO) technology. This pipeline will contribute to the advancement of translational research in CRC by bringing together CMS relevant GEMMs, orthotopic transplant models, PDOs and xenografts to couple preclinical information with clinical science.