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. 2021 Mar 22;7:31. doi: 10.1038/s41523-021-00232-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a A 68-year-old patient with DCIS that developed subsequent iIBC. The breast adipose tissue consists of large adipocytes. b Adipocytes were analysed with the vacuole module v2.1 (HALO software, Indica Labs, Corrales, NM, USA). c Beeswarm plot of the corresponding distribution of adipocyte area with mean adipocyte area and area^75th of 7287 and 10493 µm², respectively. d DCIS surrounded by small adipocytes from a 38-year-old patient. No subsequent iIBC occurred during follow-up. e Corresponding image of analysed adipocytes in HALO software. f Beeswarm plot of the corresponding distribution of adipocyte area with mean adipocyte area and area^75th of 2593 and 3274 µm², respectively.