Table 1.
Demographic data.
| ENIGMA-CNV | deCODE | |||||||
|---|---|---|---|---|---|---|---|---|
| del | nc | dup | P | del | nc | dup | P | |
| n | 28 | 37,088 | 22 | 2 | 1150 | 5 | ||
| Sex, male (%) | 15 (54%) | 17,912 (48%) | 9 (41%) | 1 (50%) | 511 (44%) | 2 (33%) | ||
| Age (mean (SD)) | 41.7 (19.0) | 61.1 (12.8) | 55.4 (12.7) | <0.001 | 53.5 (2.1) | 44.8 (12.4) | 46.4 (16.5) | |
| Children (age <18 years) | 4 (14%) | 665 (1.8%) | <0.001 | 0 | 0 | 0 | ||
| Known diagnosis (%) | 11 (39.3%) | 2424 (6.5%) | 7 (32%) | <0.001 | 238 (21%) | 2 (40%) | ||
| Disease type (%) | ||||||||
| ADHD | 1 (~0%) | 181 (16%) | 2 (40%) | |||||
| Autism | 2 (0.2%) | |||||||
| Bipolar disorder | 7 (0.6%) | |||||||
| Clinically recruited (no diagnosis) | 6 (21.4%) | 4 (18%) | ||||||
| Dyslexia | 1 (3.6 %) | |||||||
| F-ICD-10 diagnosis (UK Biobank) | 858 (2.3%) | 1 (4%) | ||||||
| G-ICD10 diagnosis (UK Biobank) | 1 (3.0%) | 1439 (3.8%) | 1 (4%) | |||||
| MDD | 1 (~0%) | |||||||
| Multiple diagnosesa | 2 (7.2%) | 1 (4.5%) | ||||||
| Persistent depressive disorder | 1 (~0%) | |||||||
| SCZ | 1 (3.6) | 124 (0.3) | 48 (4.2%) | |||||
| Scanner sites | 11 | 15 | 8 | 2 | 2 | 1 | ||
| Datasets | 9 | 13 | 7 | 1 | 1 | 1 | ||
ADHD attention deficit disorder, clinically recruited in clinical NDD study but without a diagnosis, MDD major depressive disorder, SCZ schizophrenia, del deletion carrier, nc non-carriers, dup duplication carrier, P P value, AvPD avoidant personality disorder, OCD obsessive-compulsive disorder, DPD dependent personality disorder, STPD schizotypal personality disorder, NS non-significant.
P value is based on a χ2 test for categorical values and ANOVA for continuous values.
aFirst deletion carrier: agoraphobia, AvPD, OCD, DPD, other substance-related disorder, conduct disorder. Second deletion carrier: specific phobia, social phobia, MDD, AvPD, STPD. Duplication carrier: social phobia, OCD, MDD, AvPD.