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. 2021 Mar 22;11:6497. doi: 10.1038/s41598-021-85858-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Coordination function in the P22–30 cohort of C57BL/6N, DBA/2, and FVB/N strains. (a) The grip strength test revealed increased grip strength for FVB/N mice compared to C57BL/6N and DBA/2 mice. (b) The beam balance rod test showed no difference between the three investigated strains. (c) DBA/2 mice displayed the lowest latency to fall off the grid in the inverted screen test. (d) In the cliff avoidance reaction test, DBA/2 mice exhibited the lowest latency to fall off the cliff (left) and the highest number of falls (right) compared to C57BL/6N and FVB/N mice. Two-way ANOVA followed by Tukey post hoc test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. A black rectangle indicates a significant difference between sexes within a strain (see Supplementary Table 2). Blue and red dots refer to males and females, respectively. Error bars indicate the standard error of the mean (SEM).