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. 2021 Mar 22;11:6497. doi: 10.1038/s41598-021-85858-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison between the P22–30 and P32–40 cohorts within C57BL/6N, DBA/2, and FVB/N strains. (a) The grip strength was increased with age in the three investigated strains. (b) In the beam balance rod test, only FVB/N mice showed a decreased score in older mice. (c) The latency to fall off a grid in the inverted screen test was increased in older DBA/2 mice. (d) In the cliff avoidance reaction test, FVB/N mice exhibited lower latency to fall off a cliff (left) and DBA/2 showed a decreased number of falls (right). e) The voluntary wheel running test revealed inconsistent results in different strains with C57BL/6N and FVB/N mice showing an increase in the number of rotations with age in contrast to DBA/2 mice. Two-way ANOVA followed by Tukey post hoc test,*p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001. Error bars indicate the standard error of the mean (SEM).