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. 2021 Mar 9;11:643092. doi: 10.3389/fcimb.2021.643092

Figure 2.

Figure 2

Alterations of subgingival plaque microbiota in patients with rheumatic heart disease. Microbiota of subgingival plaques (SP) from patients with rheumatic heart disease (RHD) and control subjects (Ctrl) were analyzed using 16S rRNA gene sequencing. (A) Richness of SP microbiota assessed by Chao1. (B) α-diversity of SP microbiota assessed by Shannon index. (C) β-diversity analyzed by principal coordinate analysis (PCoA) based on Bray–Curtis distance of SP microbiota at genus level. (D) Determination of module-based topological roles (peripherals, connectors, module hubs, or network hubs) of SP microbiota in RHD patients using ZP-plot at genus level. The size of dots represents abundance of each genus. (E) Relative abundances of the fifteen most abundant genera in SP microbiota. (F) Taxonomic cladogram of SP microbiota based on LEfSe. Red color indicates increase and blue indicates decrease of taxa in RHD compared to Ctrl. LDA = 3. Mann–Whitney test was used. n = 20: 20. *P < 0.05.