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. 2021 Mar 22;12:1813. doi: 10.1038/s41467-021-22034-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A total of 186 samples from 137 symptomatic COVID-19 patients were assessed concerning SARS-CoV-2 neutralization titers and grouped according to the weeks after symptom onset. a Proportions of plasma neutralization activity were stratified in 2-week intervals. b Correlation analysis of neutralization titer with S- and N-specific CLIA-reactive IgM/IgG in COVID-19 patients. A nonparametric Spearman’s correlation test was used for the statistical analyses. In the graphs, p, r, and n indicate the p value, correlation coefficient, and sample size, respectively. c Distribution of neutralizing activity at different S- and N-specific CLIA-reactive IgM/IgG. d based on the predicted cutoff value and IgG-S titer, the neutralizing activity of all confirmed patients at different time points was calculated.