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. 2021 Mar 22;5:26. doi: 10.1038/s41698-021-00160-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Growth of Myc-Cap tumor grafts suppressed by D-CAN treatment in FVB mice fed chow. Graphed is mean tumor volume ± SEM; N = 4; *P < 0.05 compared to control (Student’s t test). b Integrated heatmap of combined tumor scRNAseq data from control and D-CAN-treated mice identifying cell populations expressing genes listed vertically. c UMAP clusters of cells identified by scRNAseq in tumors. d Co-expression (red) of Cxcl12, Pdgfra, Pdgfrb, and αSMA, in stromal cells and depletion of the co-expressing sub-population (iCAF) by D-CAN treatment. Note the reduction of Fibronectin and Vimentin expression in cancer cells. e Integrated heatmap of combined SAT scRNAseq data from PBS-injected (control) and D-CAN-treated mice. Selectively expressed genes (left) identify cell clusters designated on top. f UMAP clusters of cells identified in SAT cells by combining SAT scRNAseq data from control and D-CAN-treated mice. Proliferating cells are identified based on Ki67 expression, dying cells are identified based on mitochondrial gene expression. Subpopulations of ASC expressing Dpp4, CD142, and Icam1 are indicated. g Gene expression in UMAP clusters. Note that D-CAN depletes ASC and preadipocytes (combined with the defined area) co-expressing Pdgfra, Pdgfrb, and Cxcl12. Frequencies among total SVF are indicated.