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. 2021 Mar 22;5:26. doi: 10.1038/s41698-021-00160-9

Fig. 5. CXCL12 link with age, obesity, and cancer in mice and humans.

Fig. 5

a–c RT-PCR analysis of CXCL12 mRNA expression normalized to mGapdh. a Relative CXCL12 mRNA expression in anterior prostate of 6-month- and 15-month-old HiMyc chow-fed mice; N = 3; *P < 0.05 compared to WT (Student’s t test). b Relative CXCL12 mRNA expression in anterior prostate of 6-month-old WT and HiMyc chow-fed mice; N = 5; *P < 0.05 (Student’s t test). c Relative CXCL12 mRNA expression in SAT and periprostatic (PP-AT) adipose tissue of C57BL/6 mice raised for 5 months on chow (control) or HFD (obese); N = 4–6; *P < 0.05 (Student’s t test). d Relative CXCL12 mRNA expression normalized to hGapdh in stromal cells of SAT and periprostatic AT samples from control (BMI < 30; N = 8–11) or obese (BMI > 30; N = 12–16) PCa patients. *P < 0.05 (Student’s t test). e Analysis of mRNA expression correlation between PDGFRb and CXCL12, as well as between Pdgfrb and Pdgfra, in 498 primary prostate tumors from the TCGA cohort. P and r values were calculated using Pearson correlation test. f Kaplan–Meier curves, based on data from TCGA provisional cohort, showing estimated biochemical recurrence-free probability in patients with high (z-score of upper 30%) and low (z-score of lower 70%) PDGFRb mRNA tumor expression.