Table 3.
Multivariable regression analysis of DCR, PFS, and OS
| Variables | Factor | n | DCR |
PFS |
OS |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 90% CI | P value | HR | 95% CI | P value | HR | 95% CI | P value | |||
| RAS mutation status (mutant/wild-type) | Mutant Wild-type |
49 48 |
0.48 | 0.22-1.08 | 0.1362 | 1.56 | 0.94-2.60 | 0.0870 | 1.29 | 0.76-2.20 | 0.3404 |
| Time from diagnosis of metastasis (≥18/<18 months) | ≥18 <18 |
72 25 |
1.06 | 0.43-2.65 | 0.9107 | 0.89 | 0.52-1.52 | 0.6577 | 0.89 | 0.50-1.58 | 0.6862 |
| Sex (female/male) | Female Male |
44 53 |
1.20 | 0.56-2.57 | 0.6865 | 1.14 | 0.72-1.80 | 0.5770 | 1.11 | 0.69-1.80 | 0.6649 |
| Age, years (≥65/<65) | ≥65 <65 |
49 48 |
0.68 | 0.32-1.42 | 0.3912 | 1.16 | 0.73-1.83 | 0.5325 | 0.99 | 0.61-1.60 | 0.9503 |
| Number of prior regimens (≥3/≤2) | ≥3 ≤2 |
71 26 |
0.68 | 0.26-1.73 | 0.4959 | 1.38 | 0.79-2.41 | 0.2648 | 0.95 | 0.51-1.77 | 0.8795 |
| Number of metastatic sites (≥3/≤2) | ≥3 ≤2 |
33 64 |
0.74 | 0.35-1.57 | 0.5084 | 1.55 | 0.98-2.46 | 0.0595 | 1.59 | 0.99-2.56 | 0.0550 |
| Location of primary tumor (right/left) | Right Left |
24 73 |
1.82 | 0.73-4.57 | 0.2814 | 0.53 | 0.29-0.98 | 0.0440 | 0.63 | 0.33-1.21 | 0.1650 |
CI, confidence interval; DCR, disease control rate; HR, hazard ratio; OR, odds ratio; OS, overall survival; PFS, progression-free survival.