Table 3.
Correlations between neurocognitive scores and brain volume measures with three metrics of dysglycemia in the type 1 diabetes group (longitudinal mixed-effects modeling)
| Age | ||||
|---|---|---|---|---|
| 6 years | 8 years | 10 years | 12 years | |
| Neurocognitive metrics | ||||
| HbA1c AUC >6% | ||||
| FSIQ | −0.256 (0.086) P = 0.003 |
−0.270 (0.075) P = 0.000 |
−0.298 (0.074) P = 0.000 |
−0.303 (0.075) P = 0.000 |
| PIQ | −0.171 (0.095) P = 0.071 |
−0.214 (0.081) P = 0.008 |
−0.246 (0.079) P = 0.002 |
−0.261 (0.079) P = 0.001 |
| VIQ | −0.262 (0.081) P = 0.001 |
−0.268 (0.072) P = 0.000 |
−0.297 (0.071) P = 0.000 |
−0.299 (0.075) P = 0.000 |
| % Sensor glucose >180 mg/dL | ||||
| FSIQ | −0.396 (0.103) P = 0.000 |
−0.420 (0.078) P = 0.000 |
−0.382 (0.066) P = 0.000 |
−0.287 (0.082) P = 0.000 |
| PIQ | −0.279 (0.105) P = 0.008 |
−0.330 (0.083) P = 0.000 |
−0.314 (0.073) P = 0.000 |
−0.219 (0.085) P = 0.010 |
| VIQ | −0.365 (0.095) P = 0.000 |
−0.366 (0.074) P = 0.000 |
−0.350 (0.067) P = 0.000 |
−0.320 (0.086) P = 0.000 |
| SD sensor glucose | ||||
| FSIQ | −0.397 (0.083) P = 0.000 |
−0.420 (0.073) P = 0.000 |
−0.407 (0.069) P = 0.000 |
−0.327 (0.090) P = 0.000 |
| PIQ | −0.292 (0.088) P = 0.001 |
−0.304 (0.083) P = 0.000 |
−0.289 (0.082) P = 0.000 |
−0.202 (0.097) P = 0.037 |
| VIQ | −0.385 (0.083) P = 0.000 |
−0.413 (0.072) P = 0.000 |
−0.409 (0.069) P = 0.000 |
−0.393 (0.085) P = 0.000 |
| Brain structure metrics | ||||
| HbA1c AUC >6% | ||||
| Total brain volume | −0.171 (0.082) P = 0.036 |
−0.188 (0.076) P = 0.014 |
−0.203 (0.073) P = 0.005 |
−0.207 (0.071) P = 0.004 |
| Gray matter volume | −0.149 (0.083) P = 0.073 |
−0.195 (0.076) P = 0.011 |
−0.238 (0.073) P = 0.001 |
−0.263 (0.072) P = 0.000 |
| White matter volume | −0.188 (0.079) P = 0.018 |
−0.165 (0.076) P = 0.029 |
−0.145 (0.074) P = 0.052 |
−0.120 (0.074) P = 0.104 |
| % Sensor glucose >180 mg/dL | ||||
| Total brain volume | −0.003 (0.080) P = 0.969 |
−0.028 (0.071) P = 0.693 |
−0.057 (0.069) P = 0.404 |
−0.081 (0.076) P = 0.285 |
| Gray matter volume | −0.037 (0.083) P = 0.653 |
−0.071 (0.072) P = 0.328 |
−0.101 (0.070) P = 0.152 |
−0.114 (0.079) P = 0.150 |
| White matter volume | 0.031 (0.080) P = 0.702 |
0.025 (0.073) P = 0.730 |
0.002 (0.070) P = 0.981 |
−0.029 (0.076) P = 0.702 |
| SD sensor glucose | ||||
| Total brain volume | −0.238 (0.083) P = 0.004 |
−0.221 (0.078) P = 0.005 |
−0.174 (0.078) P = 0.027 |
−0.099 (0.088) P = 0.264 |
| Gray matter volume | −0.275 (0.082) P = 0.001 |
−0.265 (0.076) P = 0.000 |
−0.217 (0.076) P = 0.004 |
−0.130 (0.087) P = 0.136 |
| White matter volume | −0.174 (0.086) P = 0.044 |
−0.148 (0.082) P = 0.071 |
−0.106 (0.082) P = 0.194 |
−0.053 (0.088) P = 0.549 |