Table 2.
Correlation analysis between Nuf2 and biomarker genes of immune cells in HCC.
| Description | Gene markers | TIMER | GEPIA | ||
|---|---|---|---|---|---|
| Cor | FDR | Cor | FDR | ||
| CD8+ T cell | CD8A | 0.272 | 6.40E-07 | 0.16 | 5.29E-03 |
| CD8B | 0.244 | 8.26E-06 | 0.13 | 1.85E-02 | |
| T cell (general) | CD3D | 0.367 | 8.53E-12 | 0.23 | 2.73E-05 |
| CD3E | 0.326 | 2.03E-09 | 0.15 | 6.10E-03 | |
| CD2 | 0.321 | 3.27E-09 | 0.17 | 3.59E-03 | |
| B cell | CD19 | 0.372 | 5.19E-12 | 0.30 | 4.48E-08 |
| CD79A | 0.291 | 9.49E-08 | 0.15 | 7.01E-03 | |
| Monocyte | CD86 | 0.418 | 4.76E-15 | 0.24 | 1.52E-05 |
| CD115 | 0.246 | 7.28E-06 | 0.11 | 5.90E-02 | |
| TAM | CCL2 | 0.154 | 5.19E-03 | 0.027 | 6.43E-01 |
| CD68 | 0.283 | 2.25E-07 | 0.16 | 4.43E-03 | |
| IL10 | 0.321 | 3.26E-09 | 0.11 | 5.48E-02 | |
| M1 Macrophage | iNOS | 0.028 | 6.20E-01 | 0.026 | 6.42E-01 |
| IRF5 | 0.437 | 2.42E-16 | 0.40 | 1.48E-13 | |
| COX2 | 0.207 | 1.65E-04 | 0.073 | 2.01E-01 | |
| M2 Macrophage | CD163 | 0.136 | 1.35E-02 | -0.012 | 8.34E-01 |
| VSIG4 | 0.170 | 2.33E-04 | 0.043 | 4.40E-01 | |
| MS4A4A | 0.194 | 3.96E-04 | 0.044 | 4.37E-01 | |
| Neutrophils | CD66b | 0.097 | 7.74E-02 | 0.07 | 2.21E-01 |
| CD11b | 0.369 | 7.51E-12 | 0.27 | 8.85E-07 | |
| CCR7 | 0.224 | 4.46E-05 | 0.067 | 2.41E-01 | |
| Natural killer cell | KIR2DL1 | -0.045 | 4.18E-01 | 0.000 | 1.00 |
| KIR2DL3 | 0.211 | 1.18E-04 | 0.15 | 6.79E-03 | |
| KIR2DL4 | 0.232 | 2.33E-05 | 0.23 | 2.75E-05 | |
| KIR3DL1 | 0.024 | 6.53E-01 | -0.054 | 3.47E-01 | |
| KIR3DL2 | 0.148 | 7.21E-03 | 0.15 | 6.47E-03 | |
| KIR3DL3 | 0.055 | 3.28E-01 | 0.11 | 4.60E-02 | |
| KIR2DS4 | 0.055 | 3.28E-01 | 0.049 | 3.90E-01 | |
| Dendritic cell | HLA-DPB1 | 0.258 | 2.57E-06 | 0.12 | 2.71E-02 |
| HLA-DQB1 | 0.231 | 2.58E-05 | 0.083 | 1.41E-01 | |
| HLA-DRA | 0.295 | 6.94E-08 | 0.16 | 5.66E-03 | |
| HLA-DPA1 | 0.256 | 2.87E-06 | 0.11 | 4.28E-02 | |
| BDCA-1 | 0.202 | 2.29E-04 | 0.097 | 8.31E-02 | |
| BDCA-4 | 0.224 | 4.47E-05 | 0.16 | 5.46E-03 | |
| CD11c | 0.442 | 1.28E-16 | 0.28 | 3.12E-07 | |
| Th1 | T-bet | 0.180 | 1.05E-03 | 0.062 | 2.83E-01 |
| STAT4 | 0.301 | 3.48E-08 | 0.23 | 3.82E-05 | |
| STAT1 | 0.414 | 8.51E-15 | 0.35 | 1.02E-10 | |
| IFN-γ | 0.337 | 5.13E-10 | 0.25 | 7.87E-06 | |
| TNF-α | 0.368 | 8.41E-12 | 0.22 | 7.54E-05 | |
| Th2 | GATA3 | 0.290 | 1.06E-07 | 0.16 | 5.48E-03 |
| STAT6 | 0.107 | 5.22E-02 | 0.15 | 7.98E-03 | |
| STAT5A | 0.277 | 3.89E-07 | 0.21 | 1.74E-04 | |
| IL13 | 0.113 | 4.03E-02 | 0.13 | 2.29E-02 | |
| Tfh | BCL6 | 0.182 | 9.58E-04 | 0.18 | 1.49E-03 |
| IL21 | 0.151 | 2.48E-03 | 0.16 | 5.45E-03 | |
| Th17 | STAT3 | 0.160 | 3.81E-03 | 0.12 | 4.08E-02 |
| IL17A | 0.121 | 2.80E-02 | 0.089 | 1.14E-01 | |
| Treg | FOXP3 | 0.240 | 1.19E-05 | 0.12 | 3.11E-02 |
| CCR8 | 0.463 | 5.47E-18 | 0.35 | 1.27E-10 | |
| STAT5B | 0.244 | 8.26E-06 | 0.27 | 1.25E-06 | |
| TGFβ | 0.347 | 1.50E-10 | 0.22 | 9.32E-05 | |
| T cell exhaustion | PD-1 | 0.407 | 2.26E-14 | 0.30 | 5.31E-08 |
| CTLA4 | 0.460 | 5.58E-18 | 0.33 | 1.36E-09 | |
| LAG3 | 0.344 | 2.14E-10 | 0.24 | 1.32E-05 | |
| TIM-3 | 0.433 | 4.18E-16 | 0.25 | 5.36E-06 | |
| GZMB | 0.154 | 5.12E-03 | 0.05 | 3.86E-01 | |
| TOX | 0.276 | 4.24E-07 | 0.18 | 1.93E-03 | |
| TIGIT | 0.409 | 1.93E-14 | 0.26 | 2.95E-06 | |
HCC, hepatocellular carcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation. FDR, false discovery rate corrected P value. Bold values indicate FDR < 0.05.