TABLE 2.

Detailed information of Seven kinds of CMIs.

Name	Source	Species, concentration	Indications a	Quality control reported? (Y/N)	Chemical analysis reported? (Y/N)
Reduning	Gardenia jasminoides J.Ellis (Fructus Gardeniae), measured as glycosides (C17H24O10) 180-280 mg, Lonicera japonica Thunb., measured as chlorogenic (C16H18O9) acid 112-168 mg, Artemisia annua L., the content is not mentioned in the pharmacopeia	Fructus Gardeniae, measured as glycosides (C17H24O10) 180-280 mg, Lonicera japonica Thunb., measured as chlorogenic (C16H18O ) acid 112mg-168 mg, Artemisia annua, the content is not mentioned in the pharmacopeia	① Infectious diseases include: Common cold, acute tracheitis and bronchitis, community acquired pneumonia, asthmatic bronchitis; ② Virus infection include: Human infection with H7N9 avian influenza, severe fever with thrombocytopenia syndrome, influenza A (H1N1), dengue fever, COVID-19; ③ Critically ill include: Sepsis, severe and critical COVID-19	Y- national food and drug administration national drug standards. Standard number: YBZ08202005-2015Z	Y- HPLC and GC
Xuebjing	Carthamus tinctorius L. (Carthami Flos), Paeonia lactiflora Pall. (Paeoniae Radix Rubra), Conioselinum tenuissimum (Nakai) Pimenov and Kljuykov (syn. Ligusticum tenuissimum Kitag.), Conioselinum anthriscoides (H.Boissieu) Pimenov and Kljuykov (syn. Ligusticum sinense Oliv.), and Conioselinum smithii (H.Wolff) Pimenov and Kljuykov (syn. Ligusticum jeholense Nakai et Kitag.) (Ligusticum Rhizoma),. Salvia miltiorrhiza Bunge (Salvia miltiorrhiza Radix), Angelica sinensis (Oliv.) Diels (Angelicae Sinensis Radix).	Carthami Flos, Paeoniae Radix Rubra, Ligusticum Rhizoma, Salvia miltiorrhiza Radix, Angelicae Sinensis Radix	① Infectious diseases include: Community acquired pneumonia ② Virus infection include: Human infection with H7N9 avian influenza, severe fever with thrombocytopenia syndrome, dengue fever, COVID-19 ③ Critically ill include: Multiple organ dysfunction syndrome in the elderly, stroke -associated pneumonia, acute pancreatitis, acute paraquat intoxication, severe and critical COVID-19, sepsis, sepsis complicated with ALI, sepsis complicated with disseminated intravascular coagulation, ALI/ARDS ④ Others: Chronic pulmonary heart disease	Y- national food and drug administration national drug standards. Standard number: YBZ01242004-2010Z-2012	N
Shenmai	Panax ginseng C. A. Mey. (Red Ginseng), measured as ginsenoside (C48H82O18) 40 mg. Ophiopogon japonicus (Thunb.) Ker Gawl. (Radix Ophiopogonis), the content is not mentioned in the pharmacopeia	Red Ginseng, measured as ginsenoside (C48H82O18) 40 mg, Radix Ophiopogonis, the content is not mentioned in the pharmacopeia	① Infectious diseases include: Community acquired pneumonia ② Virus infection include: Human infection with H7N9 avian influenza, severe fever with thrombocytopenia syndrome, dengue fever, influenza A (H1N1), COVID-19 ③ Critically ill include: Acute ischemic stroke, acute myocardial infarction, sepsis, severe and critical COVID-19 ④Others: Chronic heart failure	Y- national food and drug administration national drug standards. Standard number: WS3-B-3428-98-2010Z	Y-HPLC
Danshen	Salvia miltiorrhiza Bunge (Salvia miltiorrhiza Radix) 45 g, content 6 mg protocatechualdehyde (C7H6O3) at least	Salvia miltiorrhiza Radix 45 g, content 6 mg protocatechualdehyde (C7H6O3) at least	① virus infection include: Influenza A (H1N1) ② Critically ill include: Stroke, acute myocardial infarction, sepsis, acute pancreatitis ③ Others: Chronic pulmonary heart disease, allergic purpura disease, chronic glomerulonephritis, chronic cerebral ischemia	Y- national food and drug administration national drug standards. Standard number: WS3-B-3766-98-2011	Y-HPLC
Huangqi	Astragalus mongholicus Bunge (syn. Astragalus membranaceus) 40 g, content 1.6 mg Astragalus Saponin I (C41H68O14) at least	Astragalus membranaceus 40 g, content 1.6 mg Astragalus Saponin I (C41H68O14) at least	① Virus infection include: Chronic hepatitis B ② Critically ill include: Acute myocardial infarction, sepsis ④ Others: Chronic heart failure, chronic glomerulonephritis	Y- national food and drug administration national drug standards. Standard number: WS3-B-3335-98	Y-TLC
Tanreqing	Scutellaria baicalensis Georgi, content 100 mg baicalin (C21H18O11) at least, Fel Ursi, (content 108 mg ursodeoxycholic acid (C24H40O4) at least,. Naemorhedus goral Hardwicke, Lonicera japonica Thunb. Forsythia suspensa (Thunb.) Vahl, the content is not mentioned in the pharmacopeia	Scutellaria baicalensis Georgi, content 100 mg baicalin (C21H18O11) at least, Fel Ursi, (content 108 mg ursodeoxycholic acid (C24H40O4) at least, Naemorhedus goral Hardwicke, Lonicera japonica Thunb. Forsythia suspensa, the content is not mentioned in the pharmacopeia	① Infectious diseases include: Common cold, acute tracheitis and bronchitis, community acquired pneumonia ② Virus infection include: Human infection with H7N9 avian influenza, dengue fever, COVID-19 ③ Critically ill include: Sepsis, severe and critical COVID-19 ④ Others: Chronic pulmonary heart disease, chronic obstructive pulmonary disease	Y- national food and drug administration national drug standards. Standard number: YBZ00912003-2007Z-2009-2012	Y-HPLC
Fufangkushen	Sophora flavescens Aiton (Radix Sophorae Flavescentis), 42 g, content 540 mg matrine (C16H24N2O) at least, Smilax bockii Warb. (syn. Heterosmilax japonica Kunth),18 g	Radix Sophorae Flavescentis, 42 g, content 540 mg matrine (C16H24N2O) at least, Heterosmilax japonica Kunth,18 g	Complementary treatment of tumors	Y- national food and drug administration national drug standards. Standard number: WS3-B-2752-97-2014	Y- TLC

^aThese indications are mentioned in the clinical guidelines listed in Supplementary Data.