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. 2021 Mar 9;11:653236. doi: 10.3389/fonc.2021.653236

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Copyright © 2021 Lu, Peng, Zhong, Wu, He, Deng and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mammary tumors were induced in tree shrew by injection of lentivirus expressing the PyMT oncogene into mammary ducts (26); (B) Hepatocellular carcinoma was induced in tree shrew by inoculated with serum from HBV-infected patient or tree shrew (27). (C) A tree shrew basal cell carcinoma model was established by infecting tail skins with lentiviral SmoA1 (28). (D) Pancreatic ductal adenocarcinoma was induced in tree shrew by Injection of lentivirus expressing KRAS-shTp53-shCdkn2a/b into the pancreatic head of the tree shrew (29). (E) Malignant glioma was induced in tree shrew by engineering a lentiviral system for the transduction of mutant H-RAS and a shRNA against tree shrew p53 (H&E) (30).