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. 2021 Mar 5;20:659–668. doi: 10.1016/j.omto.2021.03.002

Figure 1.

Figure 1

Viral constructs

(A) Schematic representation of OAd-NIS vectors. Constructs are based on adenovirus type 5 (Ad5) and include deletion of the 12.5K, 6.7K, gp19K, RID-α, RID-β, and 14.7K genes from the E3 region. The ADP gene was removed from ADP– vectors. The vectors are equipped with the Ad5/Ad3-modified fiber to overcome coxsackie Ad receptor (CAR) deficiency and a Cox2 promoter to restrict replication and gene expression to permissive tumors. (B) PCR verification of ADP presence or absence in each vector.