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. 2021 Mar 22;11:6519. doi: 10.1038/s41598-021-86012-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Relative CDR1 gene expression in the C. albicans CAF2-1. Gene expression levels are reported as means ± SD of 2^−ΔΔCT values (n = 3), normalized to 1 for control conditions. (B) Cdr1p-dependent rhodamine 6G (R6G efflux) in the C. albicans CAF2-1 normalized to = 1 for untreated control; means ± SD, n = 3. (C) Fluorescence micrographs of the subcellular localization of the Cdr1-GFP protein in the C. albicans KS052 (CAF2-1 CDR1-GFP). For the experiments C. albicans was grown for 8 h in the following conditions: control without antimicrobial agents, FLC—treated with fluconazole 4 μg/mL; Capric acid—treated with capric acid 45.3 μg/mL; FLC + Capric acid—simultaneously treated with fluconazole 4 μg/mL and capric acid 45.3 μg/mL. Statistical analysis was performed by comparing the CDR1 expression level (A) or R6G fluorescence intensity (B) of cells treated with antimicrobial agent(s) with the corresponding untreated control. Scale bar = 5 μm. Statistical significance was presented as follows: **p < 0.01; ***p < 0.001.