Fig. 4. Scope of the oxime esters in asymmetric three-component alkene acylcyanation.

Reaction conditions: 1 (0.1 mmol), 3 (0.3 mmol), TMSCN (0.3 mmol), Cu(CH₃CN)₄PF₆ (1.5 mol%), ligand L1 (2.25 mol%), fac-Ir(ppy)₃ (0.8 mol%), DMA (2.5 mL), 2 × 3 W purple LEDs, at room temperature. Isolated yields were reported. The ee and d.r. values were determined by HPLC analysis on a chiral stationary phase. a With alkene 1b. b With alkene 1a.