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3D structures (shown in cartoon representation) of the most frequently mutated non-structural proteins (NSPs) along with their wild-type (WT) structure. (A) NSP2(WT), (B) NSP2[496(Q→P)], (C) NSP3(WT), (D) NSP3[994(A→V)], (E) NSP4(WT), (F) NSP4[380(A→V)], (G) NSP5(WT), (H) NSP5[254(S→F)], (I) NSP6(WT), (J) NSP6[37(L→F)], (K) NSP12(WT), (L) NSP12[323(P→L)], (M) NSP14(WT), (N) NSP14[177(L→F)], (O) NSP16(WT), and (P) NSP16[298(N→L)].
