TABLE 1.

Information of homology models/crystal structures of frequently mutated (mutation frequency ł2.5% in India) NSPs and corresponding wild type NSPs.

NSP	Mutation	Sequence length	Template/crystal structure pdb id	Verify3D (%) (Eisenberg et al., 1997)	ERRAT (%) (Colovos and Yeates, 1993)	QMEAN (Benkert et al., 2011)
NSP2	Wild typea	1–638	NA	76.96	42.05	−13.1
	496(Q→P)	1–638	Wild type	79.47	34.92	−12.34
NSP3	Wild typea	1–1945	NA	NA	50.50	−9.46
	994(A→D)	1–1945	Wild type	NA	42.87	−8.71
	1198(T→K)	1–1945	Wild type	NA	43.44	−9.03
NSP4	Wild typea	1–500	NA	72.60	49.06	−10.88
	380(A→V)	1–500	Wild type	80.20	42.87	−10.58
NSP5	Wild typeb	1–306	6w63	93.11	97.24	0.30
	254(S→F)	1–306	6w63	91.83	93.96	−0.74
NSP6	Wild type	1–290	ab initio	83.10	96.44	−2.1
	37(L→F)	1–290	Wild type	87.93	90.78	−2.45
NSP12	Wild typeb	1–932	6yyt	87.34	96.70	−1.53
	97(A→V)	1–932	6yyt	85.87	73.6	−2.19
	323(P→L)	1–932	6yyt	88.1	75.95	−1.98
NSP14	Wild typeb	1–527	5c8t	85.39	62.28	−2.6
	177(L→F)	1–527	Wild type	88.05	55.23	−2.91
NSP16	Wild typeb	1–298	6w75	76.06	90.95	−0.79
	298(N→L)	1–298	Wild type	96.31	84.43	−1.65

^aModel structure is adopted from Zhang Lab (2020). ^bCrystal structure.