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Examples of tumors and corresponding immunohistochemical stains in (A) Solid-predominant adenocarcinoma with tumor necrosis (center) and over atypia; (B) GSK-3β expression in the tumor above showing strong (3+) positivity in both nuclei and cytoplasm. Note weak GSK-3β expression in small lymphocytes (arrowheads). (C) Acinar adenocarcinoma metastatic to the parietal pleura (adipose tissue) showing (D) cytoplasmic staining in tumor cells.
