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. 2021 Mar 9;15:595049. doi: 10.3389/fnbeh.2021.595049

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Copyright © 2021 Graham, D’Ambra, Jung, Teratani-Ota, Vishwakarma, Venkatesh, Parigi, Antzoulatos, Fioravante and Wiltgen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Context learning activates vCA1 neurons that project to the basal amygdala. (A–C) Experimental design. (A) Ctb (magenta) was injected into the BA. (B) Mice were sacrificed 90 min after exploring a novel context (Ctx) or undergoing context fear conditioning (Fear). Control animals remained in their homecages (HC). (C) Example histology showing c-Fos staining in green, Ctb labeling in magenta and overlap in BA-projecting neurons (right). (D,E) The percentage of BA-projecting (Ctb+) and non-projecting (Ctb−) vCA1 neurons that expressed c-Fos in HC, Ctx and Fear groups. (F,G) The number of neurons in ventral and dorsal CA1 that expressed c-Fos in HC, Ctx and Fear groups. Data are presented as mean ± SEM. *p < 0.05.