Table 3.
“Mortality rate meta-analysis”: Sensitivity analysis
| Mortality rate | I2 | ||||
|---|---|---|---|---|---|
| Combined mean | 95% CI | Mean | 95% CI | P | |
| Overall result | |||||
| All studies included | 0.271 | 0.112–0.469 | 82.8 | 56.1–93.3 | 0.0006 |
| Sensitivity analysis according to study type | |||||
| Meta-analyses excluded | 0.241 | 0.027–0.574 | 88.6 | 68.4–95.9 | 0.0002 |
| Sensitivity analysis according to emergency type | |||||
| Only DKA patients included | 0.289 | 0.134–0.475 | 71.8 | 20.0–90.1 | 0.0138 |
| Only HHS patients included | 0.112 | 0.009–0.495 | 0.0 | 0.0–0.0 | 0.8523 |
| Only EDKA patients included | 0.000 | N/A | N/A | N/A | N/A |
| Only DKA/HHS patients included | 0.315 | 0.012–0.780 | 86.8 | 48.2–96.7 | 0.0058 |
| Sensitivity analysis according to quality assessment | |||||
| Studies of “suboptimal” quality excluded | 0.203 | 0.030–0.475 | 85.7 | 42.5–96.4 | 0.0082 |
| Sensitivity analysis according to GRADE level of evidence | |||||
| Studies of GRADE “very low” level of evidence excluded | 0.203 | 0.030–0.475 | 85.7 | 42.5–96.4 | 0.0082 |
| Sensitivity analysis at study level | |||||
| Present study (“case reports meta-analysis”) excluded | 0.241 | 0.027–0.574 | 88.6 | 68.4–95.9 | 0.0002 |
| Armeni, 2020 excluded | 0.360 | 0.207–0.529 | 67.2 | 0.0–90.5 | 0.0472 |
| Alkundi, 2020 excluded | 0.296 | 0.110–0.528 | 87.6 | 65.1–95.6 | 0.0003 |
| Chamorro-Pareja, 2020 excluded | 0.196 | 0.057–0.391 | 72.9 | 8.7–91.9 | 0.0251 |
N/A not applicable