TABLE 1.
Baseline values for minute volume (VT), tidal volume (VE), and frequency (f) under control conditions
Data are shown as the mean ± 1 S.E.M. NLX, naloxone. N = 8 per study.
| Parameter | Reversal Study | Prevention Study | |||||
|---|---|---|---|---|---|---|---|
| Vehicle (i.v.) | NLX (i.v.) | MCAM (i.v.) | Vehicle (i.v.) | Vehicle (s.c.) | MCAM (i.v.) | MCAM (s.c.) | |
| Minute volume (ml/min) | 198 ± 10 | 216 ± 13 | 212 ± 17 | 202 ± 11 | 200 ± 31 | 198 ± 22 | 200 ± 34 |
| Tidal volume (ml) | 2.15 ± 0.10 | 2.22 ± 0.16 | 2.20 ± 0.18 | 2.20 ± 0.20 | 2.30 ± 0.10 | 2.36 ± 0.21 | 2.28 ± 0.15 |
| Frequency (breaths/min) | 135 ± 13 | 130 ± 10 | 128 ± 11 | 132 ± 10 | 122 ± 17 | 132 ± 9 | 134 ± 10 |