TABLE 2.
Ventilatory parameters for minute volume (VT) tidal volume (VE), and frequency (f) after intravenous infusion of fentanyl, vehicle, saline, naloxone, or MCAM
Data are shown as the mean ± 1 S.E.M.; fentanyl (0.178 mg/kg). NLX, naloxone. N = 8.
| Parameter | Fentanyl | Vehicle | Saline | NLXa | MCAMa |
|---|---|---|---|---|---|
| Minute volume (ml/min) | 74 ± 4 | 220 ± 10 | 210 ± 25 | 205 ± 10 | 220 ± 8 |
| Tidal volume (ml) | 1.03 ± 0.02 | 1.90 ± 0.14 | 1.98 ± 0.10 | 2.20 ± 0.2 | 2.5 ± 0.10 |
| Frequency (breaths/min) | 70 ± 4 | 135 ± 5 | 135 ± 2 | 140 ± 3 | 140 ± 5 |
a
Cumulative ventilatory values 5 min after infusion of 10 mg/kg NLX or 10 mg/kg MCAM.