TABLE 3.
Reversal of fentanyl-induced ventilatory depression by MCAM and naloxone
Data are shown as the mean ± 1 S.E.M.; fentanyl (0.178 mg/kg) followed by naloxone or MCAM, N = 8.
| Parameter | Reversal with MCAM (mg/kg) | 1 Day after MCAM (mg/kg)a | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vehicle | 0.0001 | 0.001 | 0.01 | 0.1 | 1.0 | 10.0 | 0.1 | 1.0 | 10 | |
| Minute volume (ml/min) | 68 ± 4 | 64 ± 4 | 82 ± 17 | 92 ± 12 | 240 ± 8 | 340 ± 10 | 440 ± 10 | 66 ± 4 | 72 ± 3 | 210 ± 14 |
| Tidal volume (ml) | 1.05 ± 0.06 | 1.02 ± 0.1 | 1.70 ± 0.15 | 1.90 ± 0.28 | 2.5 ± 0.10 | 2.50 ± 0.8 | 2.80 ± 0.11 | 1.03 ± 0.06 | 1.08 ± 0.05 | 2.06 ± 0.8 |
| Frequency (breaths/min) | 62 ± 3 | 68 ± 2 | 138 ± 6 | 138 ± 10 | 140 ± 5 | 154 ± 2 | 164 ± 2 | 68 ± 3 | 64 ± 3 | 142 ± 2 |
| Reversal with Naloxone (mg/kg) | 1 Day after Naloxone (mg/kg)a | |||||||||
| Vehicle | 0.0001 | 0.001 | 0.01 | 0.1 | 1.0 | 10 | 0.1 | 1.0 | 10 | |
| Minute volume (ml/min) | 66 ± 6 | 68 ± 4 | 88 ± 6 | 290 ± 6 | 340 ± 10 | 440 ± 10 | 460 ± 23 | — | — | 66 ± 3 |
| Tidal volume (ml) | 1.03 ± 0.1 | 1.05 ± 0.06 | 1.90 ± 0.28 | 2.50 ± 0.10 | 2.70 ± 0.11 | 2.60 ± 0.12 | 2.72 ± 0.10 | — | — | 1.10 ± 0.08 |
| Frequency (breaths/min) | 60 ± 3 | 65 ± 3 | 138 ± 10 | 140 ± 5 | 160 ± 2 | 164 ± 2 | 162 ± 6 | — | — | 60 ± 8 |
a
Five minutes after fentanyl 1 day after reversal with MCAM or naloxone.