TABLE 4.
Prevention of fentanyl-induced ventilatory depression by MCAM administered intravenously or subcutaneously
Data are shown as the mean ± 1 S.E.M.; fentanyl (0.178 mg/kg) was administered on days after 10 mg/kg MCAM, N = 8.
| Parameter | Prevention Study | Days after MCAM (i.v.) | ||||||
|---|---|---|---|---|---|---|---|---|
| Fentanyl | Vehicle | MCAM | 1 | 3 | 6 | 13 | 21 | |
| Minute volume (ml/min) | 68 ± 4 | 220 ± 8 | 218 ± 5 | 216 ± 21 | 68 ± 3 | — | — | — |
| Tidal volume (ml) | 1.05 ± 0.06 | 1.85 ± 0.12 | 1.90 ± 0.11 | 2.00 ± 0.10 | 1.02 ± 0.10 | — | — | — |
| Frequency (breaths/min) | 65 ± 3 | 140 ± 10 | 142 ± 2 | 142 ± 3 | 62 ± 7 | — | — | — |
| Days after MCAM (s.c.) | ||||||||
| 1 | 3 | 6 | 13 | 21 | ||||
| Minute volume (ml/min) | — | — | — | 280 ± 11 | 284 ± 6 | 298 ± 12 | 150 ± 10 | 64 ± 3 |
| Tidal volume (ml) | — | — | — | 1.90 ± 0.10 | 2.00 ± 0.05 | 1.86 ± 0.11 | 1.48 ± 0.15 | 1.08 ± 0.10 |
| Frequency (breaths/min) | — | — | — | 158 ± 7 | 152 ± 2 | 162 ± 4 | 134 ± 10 | 64 ± 1 |