Fig. 6.

Aroclor1260 and CAR/PXR ablation altered ileal gene expression. Ileal mRNA levels for genes encoding proteins involved in maintenance of barrier integrity and intestinal inflammation/function including (A) Tjp1, (B) Ocln, (C) Cldn1, (D) Cldn3, (E) Muc2, (F) Reg3g, (G) Tff3 and (H) Fgf15 were measured using RT-PCR. Values are mean ± SEM, p < 0.05, a- Δ due to Aroclor1260 exposure within genotype, b, b*- Δ between WT and Car^-/- without or with Aroclor1260 exposure, c, c*- Δ between WT and Pxr^-/- without or with Aroclor1260 exposure, d, d*- Δ between Car and Pxr ablation without or with Aroclor1260 exposure.