. 2021 Mar 22;175(6):1–7. doi: 10.1001/jamapediatrics.2020.7140

Table 1. Key Model Inputs.

Parameter	Value	Range considered in sensitivity analysis	Source
Patients with SCD with severe phenotype, %	25	10-40	Assumed
Baseline annual expenditure for patient with SCD, $	42 200^a	17 100-67 250	Kauf et al,¹³ Arnold et al¹⁷
Cost of single gene therapy treatment per person, $	1 850 000	1 440 000-2 170 000	Beasley and Mathias¹⁸
Annual market diffusion rate for gene therapy, %	7	2-15	Assumed

Abbreviation: SCD, sickle cell disease.

^{^a}

Mean of estimates in associated reference.