Figure 4. SOCE controls the proliferation and clonal expansion of CD4⁺ and CD8⁺ T cells.

Ca²⁺ mediated activation of calcineurin and NFAT induces, directly or indirectly, the expression of several transcription factors such as IRF4, Myc and HIF1α, which together with NFAT regulate the expression of glucose transporters and glycolytic enzymes that support the metabolic switch of activated mouse and human T cells, their entry into the cell cycle and proliferation [41].