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. 2021 Mar 22;80(4):336–344. doi: 10.1093/jnen/nlab018

FIGURE 2.

FIGURE 2.

Isopropyl 6-diazo-5-oxo-2-(((phenyl (pivaloyloxy) methoxy) - carbonyl) amino) hexanoate (JHU395) decreases growth of multiple high MYC-expressing medulloblastoma cell lines. (A) CelltiterBlue growth assays showing JHU395 decreased growth of multiple cell lines expressing MYC at lower concentrations compared to 6-diazo-5-oxo-l-norleucine (DON). Asterisks indicate p < 0.05, double asterisks indicate p < 0.01 by 1-way ANOVA with Dunnet’s multiple comparison test compared with control on day 5. Representative graphs are shown. Each experiment was repeated a minimum of 3 times with similar results. (B) IC50 of DON and JHU395 were calculated by GraphPad Prism on different high MYC-expressing medulloblastoma cell lines.