. 2021 Mar 8;80(4):325–335. doi: 10.1093/jnen/nlab017

TABLE 2.

Linear Regression Analysis of Postmortem Variables and Cohort Characteristics

	LC neuron number	MMSE score	Diagnosis
Pontine arteriosclerosis	r² = 0.4	r² = 0.45	r² = 0.63
Pontine arteriosclerosis	p = 0.0002	p < 0.0001	p < 0.0001
LC oxidative damage	r² = 0.3	r² = 0.47	r² = 0.55
LC oxidative damage	p = 0.002	p < 0.0001	p < 0.0001
LC tau pathology	r² = 0.4	r² = 0.38	r² = 0.65
LC tau pathology	p = 0.0002	p = 0.0004	p < 0.0001
LC neuron number	X	r² = 0.4	r² = 0.38
LC neuron number		p = 0.0002	p = 0.0003
Age	r ² = 0.05	r² = 0.19	r ² = 0.04
Age	p = 0.22	p = 0.02	p = 0.27
PMI	r ² = 0.02	N/A	N/A
PMI	p = 0.5
MMSE	r² = 0.24	X	r² = 0.57
MMSE	p = 0.007		p < 0.0001
Braak stage	r ² = 0.1	r ² = 0.13	r² = 0.39
Braak stage	p = 0.09	p = 0.054	p = 0.0003
Reagan diagnosis	r ² = 0.01	r ² = 0.11	r ² = 0.12
Reagan diagnosis	p = 0.6	p = 0.07	p = 0.06
CERAD diagnosis	r ² = 0.06	r² = 0.16	r ² = 0.12
CERAD diagnosis	p = 0.2	p = 0.03	p = 0.06

CERAD, Consortium to Establish a Registry for Alzheimer Disease; LC, Locus coeruleus; MMSE, Mini-Mental State Examination. Boldface indicates significant differences.