Table 3.
The Kinase target networks of CXC chemokines in SKCM (LinkedOmics).
| CXC chemokines | Enriched kinase target | Description | Leading EdgeNum | P-value |
|---|---|---|---|---|
| CXCL 1 | Kinase_ROCK1 Kinase_RPS6KB1 |
Rho associated coiled-coil containing protein kinase 1 ribosomal protein S6 kinase B1 |
14 8 |
0 0 |
| CXCL 2 | Kinase_LCK Kinase_IKBKB |
LCK proto-oncogene, Src family tyrosine kinase inhibitor of nuclear factor kappa B kinase subunit beta |
26 8 |
0 0.0030030 |
| CXCL 3 | Kinase_MAPK12 Kinase_MYLK |
mitogen-activated protein kinase 12 myosin light chain kinase |
8 3 |
0.023569 0.015936 |
| CXCL 4 (PF 4) |
Kinase_PAK1 Kinase_MARK2 |
p21 (RAC1) activated kinase 1 microtubule affinity regulating kinase 2 |
19 6 |
0 0 |
| CXCL 5 | Kinase_FER Kinase_JAK3 |
FER tyrosine kinase Janus kinase 3 |
4 4 |
0.023256 0.034843 |
| CXCL 6 | Kinase_BCR Kinase_MAPK14 |
BCR, RhoGEF and GTPase activating protein mitogen-activated protein kinase 14 |
8 26 |
0.0031746 0 |
| CXCL 8 (IL 8) |
Kinase_ADRBK2 Kinase_EIF2AK4 |
G protein-coupled receptor kinase 3 eukaryotic translation initiation factor 2 alpha kinase 4 |
1 2 |
0.0042735 0.058366 |
| CXCL 9 | Kinase_LCK Kinase_SYK |
LCK proto-oncogene, Src family tyrosine kinase spleen associated tyrosine kinase |
24 17 |
0 0 |
| CXCL 10 | Kinase_LCK Kinase_SYK |
LCK proto-oncogene, Src family tyrosine kinase spleen associated tyrosine kinase |
22 15 |
0 0 |
| CXCL 11 | Kinase_LCK Kinase_SYK |
LCK proto-oncogene, Src family tyrosine kinase spleen associated tyrosine kinase |
20 16 |
0 0 |
| CXCL 12 | Kinase_LCK Kinase_LYN |
LCK proto-oncogene, Src family tyrosine kinase LYN proto-oncogene, Src family tyrosine kinase |
26 23 |
0 0 |
| CXCL 13 | Kinase_LCK Kinase_CSNK1E |
LCK proto-oncogene, Src family tyrosine kinase casein kinase 1 epsilon |
23 9 |
0 0 |
| CXCL 14 | Kinase_ATR Kinase_PLK1 |
ATR serine/threonine kinase polo like kinase 1 |
21 45 |
0 0 |
| CXCL 16 | Kinase_LCK Kinase_LYN |
LCK proto-oncogene, Src family tyrosine kinase LYN proto-oncogene, Src family tyrosine kinase |
21 23 |
0 0 |
| CXCL 17 | Kinase_ATR Kinase_NEK2 |
ATR serine/threonine kinase NIMA related kinase 2 |
27 5 |
0 0 |