Figure 2.

Schematic diagram of a combination therapy comprising molecular targeting drugs and PD-1/PD-L1 inhibitors. Current and emerging molecular targeting drugs. Various molecular targets expressed on T cells and tumor cells are shown. Immune molecular targets such as PD-1, LAG-3, TIM-3, TIGIT, 4-1BB, CTLA-4, IDO bound to their respective specific antibodies, triggering a positive signal to T cells response. Inhibition of VEGF and EGFR mediated angiogenesis. PD-1, programmed cell death protein-1; PD-L1, programmed death protein ligand-1; LAG3, lymphocyte activation gene-3; TIM-3, T cell immunoglobulin mucin 3; TIGIT, T cell immunoreceptor with Ig and ITIM domains; CTLA-4, cytotoxic T-lymphocyte antigen-4; IDO, indoleamine 2,3-dioxygenase; VEGF, vascular endothelial growth factor; EGFR, epidermal growth factor receptor.