Table VI.

Combination of Traditional Chinese Medicine with PD-1/PD-L1 inhibitors.

Author(s) (year)	Interventions	Primary end point(s)	Results	(Refs.)
Dong et al, 2018	Diosgenin + anti-PD-1 vs. diosgenin vs. anti-PD-1	Mean tumor weigh	1,980.00±861.22 mg vs. 3,203.33±641.43 mg vs. 2,530.00±584.04 mg	(124)
Hao et al, 2019	Icariin + anti-PD-1 + anti- CTLA-4 vs. anti-PD-1 + anti- CTLA-4	Average inhibition rates	65% vs. 34.2%	(125)
Li et al, 2019	Rhusverniciflua Stokes	The IC50 of blocking	26.22 µg/ml	(126)
		PD-1/PD-L1 interaction
Wang et al, 2019	Ganoderma lucidum	PD-1	Decreased	(127)
Su et al, 2018	Ganoderma lucidum + Paclitaxel	Tumor weight	Decreased	(128)
		Tumor infiltration lymphocytes	Increased
		PD-1, Tim-3	Inhibited

PD-1, programmed cell death protein-1; PD-L1, programmed death protein ligand-1.