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. 2021 Mar 16;23(5):374. doi: 10.3892/mmr.2021.12013

Figure 5.

Figure 5.

PF attenuates kidney injury in diabetic mice. (A) Western blot analysis of p-p66shc, total p66shc, IκBα, p-NF-κB p65, total NF-κB p65, p-IKKα/β, total IKKα/β and β-actin. (B) Densitometric analysis of p-p66shc and total p66shc. (C) Densitometric analyses of p-p66shc/p66shc and p-NF-κB p65/NF-κB p65. (D) Densitometric analyses of IκBα and p-IKKα/β/IKKα/β. (E) Representative image of the TUNEL staining; ×400 magnification; white arrowheads indicate TUNEL-positive cells. Data are expressed as the mean ± SEM, n=3. *P<0.05, **P<0.01 vs. control group; #P<0.05, ##P<0.01 vs. HG group. PF, piperazine ferulate; HG, high glucose; p-, phosphorylated; Shc, Src homology/collagen; +PF, diabetic nephropathy + PF.