Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Mar 16;23(5):374. doi: 10.3892/mmr.2021.12013

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Yang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 7. — Schematic diagram of pathways involved in the protective effects of PF against HG-induced mesangial cell injury. In the diabetic environment, HG induces glomerular mesangial cell injury, which is characterized by an increase in apoptosis, inflammatory cytokine release and mesangial matrix synthesis. PF attenuated HG-induced mesangial cell injury by inhibiting p66^Shc. PF, piperazine ferulate; HG, high glucose; Shc, Src homology/collagen; ROS, reactive oxygen species; DN, diabetic nephropathy.