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. 2021 Mar 16;23(5):367. doi: 10.3892/mmr.2021.12006

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Copyright: © Huang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — OSS-128167 aggravates hyperglycemia-induced cardiac damage. (A and B) Representative images of immunoblot analysis of SIRT6 in cardiac tissue. GAPDH was used as a loading control. (C) Chemical structure of the SIRT6 inhibitor OSS-128167. (D) Representative histomorphometric images of H&E staining of myocardial tissues from each group fixed with formalin (magnification, ×400). (E) Representative micrographs of Masson trichrome staining of myocardial tissues (magnification, ×400). (F) Heart tissues underwent TUNEL assay (magnification, ×400); the lower panel is a partially enlarged image of the upper panel (magnification, ×1,200). n=6-9. ***P<0.001 vs. Vehicle. SIRT6, sirtuin 6; H&E, hematoxylin and eosin; STZ, streptozotocin; STZ-DM1, STZ-induced diabetes.