TABLE 1.

Factor V activity and antigen levels in Covid‐19 patients related to severity of disease and mortality

	Factor V activity (%)	Factor V antigen (%)	Factor V specific activity a
Healthy controls (n = 28)	107 [84–124]	81 [66–98]	1.26 [1.12–1.48]
Covid‐19 patients (n = 97)	125 [102–145]	93 [67–137]	1.33 [0.87–1.86]
P‐value	.002	.072	.868
Covid‐19 patients stratified by location
General ward (n = 85)	124 [100–144]	92 [67–126]	1.39 [0.98–1.91]
High care b (n = 12)	142 [124–149]	158 [106–184]	0.93 [0.66–1.16]
P value	.103	.007	.007
Covid‐19 patients stratified by level of respiratory support
No respiratory support (n = 36)	124 [103–141]	92 [63–126]	1.37 [0.94–1.91]
Nasal cannula/mask ≤5 Liter O2 (n = 45)	125 [96–148]	92 [68–128]	1.39 [0.98–1.89]
Higher respiratory support c (n = 17)	128 [103–150]	126 [61–183]	1.16 [0.83–1.60]
P value	.472	.173	.446
Covid‐19 patients stratified by 30‐day survival
Survivors (n = 87)	126 [61–183]	97 [68–130]	1.35 [0.92–1.89]
Non‐survivors (n = 10)	97 [78–123]	59 [51–166]	1.32 [0.86–1.77]
P value	.030	.380	.752

Note: The results are presented as median [interquartile range]. Comparisons were made using the Mann–Whitney U test or Kruskal‐Wallis test, as appropriate. P values <.05 were considered statistically significant.

^aFactor V specific activity is defined as the FV activity to antigen ratio.

^bThree patients were admitted to the intensive care unit and nine patients were admitted to the intermediate care unit.

^cRespiratory support in this group comprised >5 L O₂ by nasal cannula/mask (n = 13), non‐invasive ventilation (n = 2), and intubation (n = 2).